British Columbia Research Articles

Advance care planning in British Columbia: awareness and engagement (2012–2020)

ObjectivesThis study examines trends in advance care planning (ACP) awareness, engagement, attitude and experiences among the public in British Columbia (BC), Canada, from 2012 to 2020. This time period is...

Prediction of Postoperative Urinary Tract Infection Following Benign Gynecologic Surgery.

The objective was to develop a prediction model for urinary tract infection (UTI) after pelvic surgery. We utilized data from three tertiary care centers of women undergoing pelvic surgery. The primary outcome was a UTI within 8weeks of surgery. Additional variables collected included procedural data, severity of prolapse, use of mesh, anti-incontinence surgery, EBL, diabetes, steroid use, estrogen use, postoperative catheter use, PVR, history of recurrent UTI, operative time, comorbidities, and postoperative morbidity including venous thromboembolism, surgical site infection. Two datasets were used for internal validation, whereas a third dataset was used for external validation. Algorithms that tested included the following: multivariable logistic regression, decision trees (DTs), naive Bayes (NB), random forest (RF), gradient boosting (GB), and multilayer perceptron (MP). For the training dataset, containing both University of British Columbia and Mayo Clinic Rochester data, there were 1,657 patients, with 172 (10.4%) UTIs; whereas for the University of Calgary external validation data, there were a total of 392 patients with a UTI rate of 16.1% (n = 63). All models performed well; however, the GB, DT, and RF models all had an area under the curve (AUC) > 0.97. With external validation the model retained high discriminatory ability, DT: AUC = 0.88, RF: AUC = 0.88, and GB: AUC = 0.90. A model with high discriminatory ability can predict UTI within 8weeks of pelvic surgery. Future studies should focus on prospective validation and application of randomized trial models to test the utility of this model in the prevention of postoperative UTI.

Retrospective Cohort Study on the Impact of the COVID-19 Pandemic on Pregnancy Outcomes for Women Living With HIV in British Columbia.

For pregnant women living with HIV (WLWH), engagement in care is crucial to maternal health and reducing the risk of perinatal transmission. To date, there have been no studies in Canada examining the impact of the COVID-19 pandemic on pregnant WLWH. This was a retrospective cohort study assessing the impact of the pandemic on perinatal outcomes for pregnant WLWH using data from the Perinatal HIV Surveillance Program in British Columbia, Canada. We compared maternal characteristics, pregnancy outcomes, and clinical indicators related to engagement with care between a prepandemic (January 2017-March 2020) and pandemic cohort (March 2020-December 2022). We investigated preterm birth rates with explanatory variables using logistic regression analysis. The prepandemic cohort (n = 87) had a significantly (P < 0.05) lower gestational age at the first antenatal encounter (9.0 vs 11.8) and lower rates of preterm births compared with the pandemic cohort (n = 56; 15% vs 37%). Adjusted odds of preterm birth increased with the presence of substance use in pregnancy (aOR = 10.45, 95% confidence interval: 2.19 to 49.94) in WLWH. There were 2 cases of perinatal transmission of HIV in the pandemic cohort, whereas the prepandemic cohort had none. The pandemic had pronounced effects on pregnant WLWH and their infants in British Columbia including higher rates of preterm birth and higher gestational age at the first antenatal encounter. The nonstatistically significant increase in perinatal transmission rates is of high clinical importance.

Transepithelial phototherapeutic keratectomy for treatment-resistant recurrent corneal erosion syndrome.

To evaluate the efficacy and safety of trans-epithelial phototherapeutic keratectomy (TE-PTK) as a treatment for recurrent corneal erosion syndrome (RCES) in patients with symptoms refractory to conventional treatments. All patients who received TE-PTK treatment for RCES had failed 3 or more conventional treatments and were reviewed, and if met criteria, approved by healthcare workers of the British Columbia public health authority (Medical Services Plan (MSP). A retrospective chart review and telephone survey were conducted at the Pacific Laser Eye Centre (PLEC). Exclusion criteria were ocular co-morbidities potentially affecting treatment efficacy. This study included 593 eyes of 555 patients (46.2% male; 50.9 ± 14.2years old) who underwent TE-PTK. The leading identified causes of RCES were trauma (45.7%) and anterior basement membrane dystrophy (44.2%). The most common pre-PTK interventions were ocular lubricants (90.9%), hypertonic solutions (77.9%), and bandage contact lenses (50.9%). Thirty-six eyes had undergone surgical interventions such as stromal puncture, epithelial debridement, or diamond burr polishing. Post-PTK, 78% of patients did not require any subsequent therapies and 20% required ongoing drops. Six patients (1.1%) reported no symptom improvement and required repeat TE-PTK for ongoing RCES symptoms after initial TE-PTK. All 6 eyes were successfully retreated with TE-PTK (average time to retreatment was 11.3 ± 14.9months). There was no significant difference in best corrected visual acuity pre- vs. post-operatively. The mean post-operative follow-up was 60.5months (range: 5-127months). TE-PTK has a good efficacy and safety profile for treatment-resistant RCES. The third-party public health-reviewed nature of this study, the low recurrence rate of RCES, and the low PTK retreatment rate suggest that TE-PTK might be considered for wider use in the management of RCES.

First report of Phytophthora infestans genotype US17 causing late blight on potato and tomato in British Columbia, Canada

Potato and tomato are grown in all Canadian provinces and contribute billions of dollars in exports and sales. Late blight, caused by Phytophthora infestans, is a destructive disease of potato and tomato worldwide and is responsible for millions of dollars in losses annually. Changes in pathogen strains were reported to be associated with late blight epidemics in several regions and pose challenges to late blight management. In British Columbia (BC), diverse strains of P. infestans were reported. Using multiplex microsatellite or simple sequence repeat (SSR) markers, we identified the new genotype US17 of P. infestans from samples of potato and tomato with late blight in BC. All isolates were of the A1 mating type. One, five, and one isolates were sensitive, moderately resistant, and highly resistant to metalaxyl-m, respectively. This is the first report of the occurrence of the US17 genotype in BC and Canada. The US17 strain was also able to cause tuber rot and foliar blight symptoms in potato in pathogen-inoculated assays.

Practicing Surgeons’ Perception of Barriers to Palliative Care Delivery in British Columbia

Practicing Surgeons’ Perception of Barriers to Palliative Care Delivery in British Columbia

Long Term Second Malignancies in Prostate Cancer Patients Treated with Low-Dose-Rate Brachytherapy and Radical Prostatectomy.

Second malignancy is a rare but potentially lethal event after prostate brachytherapy, but data remain scarce on its long-term risk. The objective of this study is to estimate the number of pelvic second malignancies following brachytherapy compared to prostatectomy (RP). Retrospective review of patients treated with low dose 125I brachytherapy and prostatectomy in British Columbia from 1999 to 2010. Kaplan Meier (KM) estimates for pelvic (bladder and rectum), invasive pelvic, any second malignancy and death from any second malignancy were assessed. Cox multivariable analyses were performed adjusting for initial treatment type, age, post RP adjuvant/salvage EBRT status, and smoking history. Two thousand three hndred seventy-eight brachytherapy and 9089 prostatectomy patients were included. Median age was 66 years (IQR 61-71) and 63 years (IQR 58-67), respectively. Median follow-up time to event or censured was 14 years (IQR 11.5-17.3). The KM estimates for pelvic second malignancy at 15 and 20 years were 6.4% and 9.8% after brachytherapy, and 3.2% and 4.2% after prostatectomy. Time to any second malignancy and time to death from any second malignancy were not significantly different (P > .05). On Cox-multivariable analysis, brachytherapy, compared to surgery, was an independent factor for pelvic (HR 1.81 [95% CI 1.45-2.26], P < .001) and invasive pelvic second malignancy (HR 2.13 [95% CI 1.61-2.83], P < .001). Increased age and smoking were also associated with higher estimates of events (P < .001). After adjustment for age, post RP adjuvant/salvage EBRT status and smoking status, numerically higher long-term HRs of pelvic and invasive pelvic second malignancy in patients treated with brachytherapy compared to radical prostatectomy were noted.

Validating use of diagnostic codes in Canadian administrative data for identification of adverse drug events.

While diagnostic codes from administrative health data might be a valuable source to identify adverse drug events (ADEs), their ability to identify unintended harms remains unclear. We validated claims-based diagnosis codes for ADEs based on events identified in a prospective cohort study and assessed whether key attributes predicted their documentation in administrative data. This was a retrospective analysis of 3 prospective cohorts in British Columbia, from 2008 to 2015 (n = 13 969). We linked prospectively identified ADEs to administrative insurance data to examine the sensitivity and specificity of different diagnostic code schemes. We used logistic regression to assess which key attributes (e.g., type of event, symptoms and culprit medications) were associated with better documentation of ADEs in administrative data. Among 1178 diagnosed events, the sensitivity of the diagnostic codes in administrative data ranged from 3.4 to 52.6%, depending on the database and codes used. We found that documentation was worse for certain types of ADEs (dose-related: odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.15, 0.69; nonadherence events (OR: 0.35, 95% CI: 0.20, 0.62), and better for those experiencing arrhythmias (OR: 4.19, 95% CI: 0.96, 18.28). ADEs were not well documented in administrative data. Alternative methods should be explored to capture ADEs for health research.

Exploring the genesis & praxis of Restorative Justice in Alberta, Canada

ABSTRACT Alberta is located in Western Canada, and is bordered by British Columbia to the west, and Saskatchewan to the east. The province has a history of employing restorative justice practices that date back many years. Today, Alberta has many restorative justice platforms operating across the province. The present study sought to uncover the genesis of restorative justice in Alberta, and specifically, what has contributed to the growth of restorative justice in this province. To do this, we conducted a qualitative study, in which we interviewed 13 Key Informants from across Alberta. Responses to the question of what contributed to the growth of restorative justice in Alberta were coded and analyzed. The findings of this study are categorized into three major themes: Community, Justice System, and Government. Each of these themes explores several topics, such as community engagement and the push from grassroots organizations, the role of courts, RCMP, judges, and other leaders in the justice system, as well as government funding and programming. This presentation also explores the ‘restorativeness’ of specialized courts such as the Calgary Indigenous Court; a topic that is becoming especially important in recent years. This paper ends with limitations and areas for future research.

Reach of GetCheckedOnline among gay, bisexual, transgender and queer men and Two-Spirit people and correlates of use 5 years after program launch in British Columbia, Canada

ObjectivesUnderstanding who uses internet-based sexually transmitted and blood-borne infection (STBBI) services can inform programme implementation, particularly among those most impacted by STBBIs, including gender and sexual minority (GSM) men. GetCheckedOnline,...

Characterization of the Benefits and Risks of Therapeutic Anticoagulation in Patients Admitted with Severe COVID-19 (CRITAC).

Severe COVID-19 is associated with increased rates of thrombotic complications. Recent provincial recommendations in British Columbia have suggested providing thromboprophylaxis with therapeutic anticoagulation for hospital inpatients with severe COVID-19 who do not have a high risk of bleeding. To characterize the rates of major bleeding, thrombotic events, complications from COVID-19, and adverse effects among patients with severe COVID-19 treated with therapeutic anticoagulation. This retrospective chart review involved patients with laboratory-confirmed COVID-19 who were admitted to 3 sites within a local health authority between April 1 and December 31, 2021, and received therapeutic anticoagulation for thromboprophylaxis. After screening of 1036 patients, 72 patients were included in the study. The mean age of participants was 54 years, 63% (n = 45) were male, and 92% (n = 66) were receiving supplemental oxygen by nasal prongs on admission. The primary outcome, major bleeding, was experienced by 1 patient (1%). Increasing oxygen requirements resulting in progression to high-flow nasal cannula occurred in 11 patients (15%), and 5 patients (7%) required admission to the intensive care unit. One patient (1%) experienced a thrombotic event, and 1 patient (1%) had a minor bleed. The mean duration of hospitalization was 10 (standard deviation 10.8) days. One death occurred during the study period, and no cases of heparin-induced thrombocytopenia were observed. In this study of hospital inpatients with severe COVID-19 who were deemed to be at low risk of bleeding and who received therapeutic anticoagulation, there were low rates of both major bleeding and thrombotic events.

Canada’s Geothermal Energy Update in 2023

Geothermal energy exploration, development, and research have been ongoing in Canada for several decades. The country’s cold climate and the push to develop renewable energy sources have driven interest in geothermal energy. Despite this drive, regulatory complexities and competition with other relatively inexpensive energy sources with existing infrastructure have hindered development. As such, interest has grown and waned with changes in the energy economy over several decades, leaving many projects at a standstill. As of January 2023, there are currently no operational geothermal power projects in Canada. Many hot spring pool and spa complexes remain active, and Canada is a leading country in the installation of ground source heat pumps (GSHPs; also called geo-exchange systems). However, in the last decade, the interest in deep geothermal systems has renewed, with many new projects starting up across several provinces and territories. Moreover, projects that had shown limited progress for many years—such as Mount Meager in British Columbia—have begun to renew their development efforts. Research is also expanding within prominent research groups and universities. The areas of focus include both building upon previous studies (such as thermal gradients and the heat flow in sedimentary basins) and researching new methods and resources (such as GSHPs, closed-loop systems, integrated geothermal operations, and hybrid systems, including heat storage). The development is supported by federal, provincial, and territorial governments through grants and the development of regulatory frameworks. Although challenges still remain for Canada to develop its geothermal energy resources, several power, thermal, and co-production projects, ongoing research, funding, and regulatory acts are all moving forward to support geothermal development. This paper aims to study Canada’s geothermal energy update in 2023 regarding the aspects mentioned above.

The landscape of heat pump adoption in Canada: a market segments approach

Heat pumps are an important technology for reducing residential building emissions, however their adoption rate in North America is far below what is needed to meet emission reduction targets. This paper uses a representative web-based survey of Canadian homeowners (n = 3,804) to identify and describe characteristic and attitudinal trends of three market segments of Canadian homeowners: Pioneers (heat pump owners), Potential Early Mainstream buyers (homeowners currently willing to purchase a heat pump), and Late Mainstream buyers (homeowners currently unwilling to purchase a heat pump). We find that personal capability, contextual and attitudinal factors are significant determinants of market segments. For example, being younger, more educated and wealthier is positively associated with market segmentation in Canada. A novel finding is that voting and living in rural areas is strongly associated with willingness to install a heat pump. The Atlantic Provinces, Quebec and British Columbia are all more likely than Ontario and Alberta to adopt heat pumps while the Prairies are less likely. This is true even after controlling for personal capability, contextual and attitudinal variables. We find an important role for contextual variables in explaining the geographical distribution of heat pump market segments.

Contesting colonial beachheads: Settler colonial (in)security professionals and Indigenous peoples’ energy infrastructure

In April 2020, the British Columbia Utilities Commission released the Final Report of its Indigenous Utilities Regulation Inquiry. The Inquiry was tasked with determining the regulatory environment for Indigenous utility providers across the Canadian province. We analyse the Inquiry as a colonial encounter between Indigenous nations and the settler state, arguing that technical bodies like the Commission represent a sort of security professional working to depoliticize the reproduction of settler sovereignty, highlighting the operations of non-traditional security professionals in settler colonial contexts. Through the Inquiry, security comes through providing certainty for existing energy infrastructure and institutions as ‘colonial beachheads’, legitimizing the settler colonial political-economic order. However, the Inquiry also demonstrates that such processes offer opportunities for Indigenous nations to contest that order. Indeed, Indigenous nations used the Inquiry to both contest the legitimization of settler sovereignty and accumulation, and press for the capacity to build their own infrastructure and institutions, thereby enacting their decision-making authority. We explore this tension in the context of the contemporary reconciliation discourse, finding the Inquiry’s final recommendations represent an attempt to reify settler sovereignty, while also deepening settler insecurity through the possibilities opened for greater Indigenous self-determination.

Symptom Burden and Time from Symptom Onset to Cancer Diagnosis in Patients with Early-Onset Colorectal Cancer: A Multicenter Retrospective Analysis

Background: The incidence of colorectal cancer (CRC) is decreasing in individuals &gt;50 years due to organised screening but has increased for younger individuals. We characterized symptoms and their timing before diagnosis in young individuals. Methods: We identified all patients diagnosed with CRC between 1990–2017 in British Columbia, Canada. Individuals &lt;50 years (n = 2544, EoCRC) and a matched cohort &gt;50 (n = 2570, LoCRC) underwent chart review to identify CRC related symptoms at diagnosis and determine time from symptom onset to diagnosis. Results: Across all stages of CRC, EoCRC presented with significantly more symptoms than LoCRC (Stage 1 mean ± SD: 1.3 ± 0.9 vs. 0.7 ± 0.9, p = 0.0008; Stage 4: 3.3 ± 1.5 vs. 2.3 ± 1.7, p &lt; 0.0001). Greater symptom burden at diagnosis was associated with worse survival in both EoCRC (p &lt; 0.0001) and LoCRC (p &lt; 0.0001). When controlling for cancer stage, both age (HR 0.87, 95% CI 0.8–1.0, p = 0.008) and increasing symptom number were independently associated with worse survival in multivariate models. Conclusions: Patients with EoCRC present with a greater number of symptoms of longer duration than LoCRC; however, time from patient reported symptom onset was not associated with worse outcomes.

Prescribing practices in opioid agonist treatment and changes in compliance to clinical dosing guidelines in British Columbia, Canada.

In British Columbia, Canada, clinical guidelines for the treatment of opioid use disorders (OUD) were updated in 2017, during a period in which the potency and composition of the illicit drug supply changed rapidly. We aimed to describe changes in opioid agonist treatment (OAT) prescribing practices at the population level in a setting in which fentanyl and its analogs have become the primary illicit opioid of use. This was a population-based retrospective cohort study using three linked health administrative databases in British Columbia (BC), Canada. All individuals with at least one OAT dispensation in BC between 1 January 2014 and 31 August 2021 took part. To assess changes in OAT prescribing practices over time, we calculated initiation doses, dose titration intervals, maintenance doses and take-home dosing intervals stratified by medication [methadone, buprenorphine-naloxone and slow-release oral morphine (SROM)] according to recommended guidelines. A total of 265 410 OAT episodes (57.5% on methadone, 34.5% on buprenorphine-naloxone and 8.0% on SROM) were initiated during the study period. Compared with the guideline recommendation, observed initiation doses were higher among all medications from 2014 (2017 for SROM) to 2021(buprenorphine-naloxone: 14-29%; methadone: 53-66%; SROM: 26-55%). Titration intervals were shorter for all medications, consistent with guidelines for buprenorphine-naloxone (26-49%), but shorter than recommended for methadone or SROM (28-51% and 12-41%, respectively). Higher maintenance dosing was observed for methadone (68-78%) and SROM (3-21%). Take-home allowances extending beyond the recommended guideline length increased across medications (buprenorphine-naloxone: 18-35%; methadone: 50-64%; SROM: 34-39%). Changes in prescribing patterns were similar for first-time OAT initiators. In British Columbia, Canada, from 2014 to 2021, prescribers of opioid agonist treatment (OAT) appeared to initiate both new and experienced OAT clients at higher doses than guideline recommendations, titrate them more rapidly and maintain clients at higher doses. Take-home dose allowances also gradually increased.

Adapting care provision in family practice during the COVID-19 pandemic: a qualitative study exploring the impact of primary care reforms in four Canadian regions

BackgroundOver the past two decades, Canadian provinces and territories have introduced a series of primary care reforms in an attempt to improve access to and quality of primary care services, resulting in diverse organizational structures and practice models. We examine the impact of these reforms on family physicians’ (FPs) ability to adapt their roles during the COVID-19 pandemic, including the provision of routine primary care.MethodsAs part of a larger case study, we conducted semi-structured qualitative interviews with FPs in four Canadian regions: British Columbia, Newfoundland and Labrador, Nova Scotia, and Ontario. During the interviews, participants were asked about their personal and practice characteristics, the pandemic-related roles they performed over different stages of the pandemic, the facilitators and barriers they experienced in performing these roles, and potential roles FPs could have filled. Interviews were transcribed and a thematic analysis approach was applied to identify recurring themes in the data.ResultsSixty-eight FPs completed an interview across the four regions. Participants described five areas of primary care reform that impacted their ability to operate and provide care during the pandemic: funding models, electronic medical records (EMRs), integration with regional entities, interdisciplinary teams, and practice size. FPs in alternate funding models experienced fewer financial constraints than those in fee-for-service practices. EMR access enhanced FPs’ ability to deliver virtual care, integration with regional entities improved access to personal protective equipment and technological support, and team-based models facilitated the implementation of infection prevention and control protocols. Lastly, larger group practices had capacity to ensure adequate staffing and cover additional costs, allowing FPs more time to devote to patient care.ConclusionsRecent primary care system reforms implemented in Canada enhanced FPs’ ability to adapt to the uncertain and evolving environment of providing primary care during the pandemic. Our study highlights the importance of ongoing primary care reforms to enhance pandemic preparedness and advocates for further expansion of these reforms.

Small mouth, big appetite: diet analysis of invasive smallmouth bass (Micropterus dolomieu) in Cultus Lake, British Columbia

Small mouth, big appetite: diet analysis of invasive smallmouth bass (Micropterus dolomieu) in Cultus Lake, British Columbia

Local and regional variation in kelp loss and stability across coastal British Columbia

Kelp forests are among the most abundant coastal marine habitats but are vulnerable to climate change. The Northeast Pacific has experienced recent large-scale changes in kelp abundance and distribution, but little is known about changes north of the British Columbia (BC)-Washington border. Here, we assessed whether and how floating canopy kelp (Macrocystis pyrifera, Nereocystis luetkeana) distributions have changed in recent decades along the extensive coast of BC. We assembled and analysed available kelp distributional data, comparing snapshots of kelp linear extent from 1.5-3 decades ago (1994-2007) to recently collected data (2017-2021) across 11 different subregions spanning the province. We then leveraged timeseries, where available (n = 7 data sets), to contextualise patterns of change. In aggregate, the data suggest that kelp forests have declined considerably in some parts of the province, but with variable patterns of change across BC. In the warmest areas (southern BC), kelp persistence was negatively correlated with mean summer sea surface temperatures, which at times exceeded known thermal tolerances. In contrast, in northern subregions, top-down control by sea urchins and otters appeared to modulate kelp dynamics, with declines occurring in 2 subregions despite cool ocean temperatures. Timeseries data suggest that many declines occurred around the 2014-2016 marine heatwave, an event associated with sustained warming and altered trophic dynamics. Our results suggest that the extent of BC’s kelp forests has declined in some places in recent decades, but that regional and local-scale factors influence their responses to environmental change.

Expanding access to healthcare for people who use drugs and sex workers: hepatitis C elimination implications from a qualitative study of healthcare experiences in British Columbia, Canada

BackgroundHepatitis C virus (HCV) is a major health threat in Canada. In British Columbia (BC) province, 1.6% of the population had been exposed to HCV by 2012. Prevalence and incidence of HCV are very high in populations of people who use drugs (PWUD) and sex workers (SW), who may experience unique barriers to healthcare. Consequently, they are less likely to be treated for HCV. Overcoming these barriers is critical for HCV elimination. This research sought to explore the healthcare experiences of PWUD and SW and how these experiences impact their willingness to engage in healthcare in the future, including HCV care.MethodsInterpretive Description guided this qualitative study of healthcare experiences in BC, underpinned by the Health Stigma and Discrimination framework. The study team included people with living/lived experience of drug use, sex work, and HCV. Twenty-five participants completed in-depth semi-structured interviews on their previous healthcare and HCV-related experiences. Thematic analysis was used to identify common themes.ResultsThree major themes were identified in our analysis. First, participants reported common experiences of delay and refusal of care by healthcare providers, with many negative healthcare encounters perceived as rooted in institutional culture reflecting societal stigma. Second, participants discussed their choice to engage in or avoid healthcare. Many avoided all but emergency care following negative experiences in any kind of healthcare. Third, participants described the roles of respect, stigma, dignity, fear, and trust in communication in healthcare relationships.ConclusionsHealthcare experiences shared by participants pointed to ways that better understanding and communication by healthcare providers could support positive change in healthcare encounters of PWUD and SW, who are at high risk of HCV infection. More positive healthcare encounters could lead to increased healthcare engagement which is essential for HCV elimination.